Neurodegenerative disorders: Parkinson's disease and Huntington's disease

Neurodegenerative disorders: Parkinson's disease and Huntington's disease.

Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and t...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Neurodegenerative Disease & Movement Disorders A clinical perspective into early stages of neurodegenerative disease

Advances in therapeutical strategies for neurodegenerative diseases would reduce the burden related to these diseases. To test effectively compounds for diseases such as Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), or Alzheimer’s disease (AD) bring therapy to individuals as early as possible, there is an urgent need for the establishment of standards and networks for iden...

Neurodegenerative Disease Parkinson’s Disease

Oral levodopa remains the most effective symptomatic drug for Parkinson’s disease (PD); however, its long-term use is limited by the emergence of motor fluctuations and involuntary movements, particularly in young-onset patients. A growing number of pre-clinical and clinical studies suggest that non-physiological pulsatile stimulation of striatal dopamine (DA) receptors induced by the use of sh...

Copper Status in Alzheimer's Disease and Other Neurodegenerative Disorders 2013

1 Department of Neuroscience, AFaR-Ospedale “San Giovanni Calibita” Fatebenefratelli, Isola Tiberina, 00186 Rome, Italy 2 Neurodegeneration Laboratory, IRCCS San Raffaele Pisana, 00166 Rome, Italy 3 Department of Neurology, University Hospital Utrecht, 3584 CX Utrecht, The Netherlands 4Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 4810...